WO2005068643A3 - Biochemical synthesis of 6-amino caproic acid - Google Patents

Biochemical synthesis of 6-amino caproic acid Download PDF

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Publication number
WO2005068643A3
WO2005068643A3 PCT/EP2005/000555 EP2005000555W WO2005068643A3 WO 2005068643 A3 WO2005068643 A3 WO 2005068643A3 EP 2005000555 W EP2005000555 W EP 2005000555W WO 2005068643 A3 WO2005068643 A3 WO 2005068643A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid
caproic acid
amino
amino caproic
relates
Prior art date
Application number
PCT/EP2005/000555
Other languages
French (fr)
Other versions
WO2005068643A2 (en
Inventor
Petronella C Raemakers-Franken
Petrus Martinus Matheus Nossin
Paul Maria Brandts
Marcel Gerhardus Wubbolts
Wijnand Peter Helena Peeters
Sandra Ernste
Wildeman Stefaan Marie Andr De
Martin Schuermann
Original Assignee
Dsm Ip Assets Bv
Petronella C Raemakers-Franken
Petrus Martinus Matheus Nossin
Paul Maria Brandts
Marcel Gerhardus Wubbolts
Wijnand Peter Helena Peeters
Sandra Ernste
Wildeman Stefaan Marie Andr De
Martin Schuermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Petronella C Raemakers-Franken, Petrus Martinus Matheus Nossin, Paul Maria Brandts, Marcel Gerhardus Wubbolts, Wijnand Peter Helena Peeters, Sandra Ernste, Wildeman Stefaan Marie Andr De, Martin Schuermann filed Critical Dsm Ip Assets Bv
Priority to CN2005800027573A priority Critical patent/CN1926240B/en
Priority to EP05706939A priority patent/EP1706501B1/en
Priority to BRPI0506942-4A priority patent/BRPI0506942B1/en
Priority to AT05706939T priority patent/ATE455181T1/en
Priority to AU2005205188A priority patent/AU2005205188B2/en
Priority to DE602005018898T priority patent/DE602005018898D1/en
Priority to US10/586,132 priority patent/US7491520B2/en
Publication of WO2005068643A2 publication Critical patent/WO2005068643A2/en
Publication of WO2005068643A3 publication Critical patent/WO2005068643A3/en
Priority to US12/318,805 priority patent/US20090137759A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Abstract

The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.
PCT/EP2005/000555 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid WO2005068643A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN2005800027573A CN1926240B (en) 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid
EP05706939A EP1706501B1 (en) 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid
BRPI0506942-4A BRPI0506942B1 (en) 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid
AT05706939T ATE455181T1 (en) 2004-01-19 2005-01-17 BIOCHEMICAL SYNTHESIS OF 6-AMINOCAPROIC ACID
AU2005205188A AU2005205188B2 (en) 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid
DE602005018898T DE602005018898D1 (en) 2004-01-19 2005-01-17 BIOCHEMICAL SYNTHESIS OF 6-AMINOCAPRONIC ACID
US10/586,132 US7491520B2 (en) 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid
US12/318,805 US20090137759A1 (en) 2004-01-19 2009-01-08 Biochemical synthesis of 6-amino caproic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04075079.6 2004-01-19
EP04075079 2004-01-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/318,805 Division US20090137759A1 (en) 2004-01-19 2009-01-08 Biochemical synthesis of 6-amino caproic acid

Publications (2)

Publication Number Publication Date
WO2005068643A2 WO2005068643A2 (en) 2005-07-28
WO2005068643A3 true WO2005068643A3 (en) 2005-11-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/000555 WO2005068643A2 (en) 2004-01-19 2005-01-17 Biochemical synthesis of 6-amino caproic acid

Country Status (11)

Country Link
US (2) US7491520B2 (en)
EP (2) EP2194139A1 (en)
CN (2) CN102285893A (en)
AT (1) ATE455181T1 (en)
AU (1) AU2005205188B2 (en)
BR (1) BRPI0506942B1 (en)
DE (1) DE602005018898D1 (en)
MY (1) MY141797A (en)
TW (1) TWI371490B (en)
WO (1) WO2005068643A2 (en)
ZA (1) ZA200605764B (en)

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US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
US9260729B2 (en) 2008-03-05 2016-02-16 Genomatica, Inc. Primary alcohol producing organisms
US9562241B2 (en) 2009-08-05 2017-02-07 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid

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US8404465B2 (en) 2009-03-11 2013-03-26 Celexion, Llc Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691553B2 (en) 2008-01-22 2014-04-08 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US9051552B2 (en) 2008-01-22 2015-06-09 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US9260729B2 (en) 2008-03-05 2016-02-16 Genomatica, Inc. Primary alcohol producing organisms
US8993285B2 (en) 2009-04-30 2015-03-31 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
US9017983B2 (en) 2009-04-30 2015-04-28 Genomatica, Inc. Organisms for the production of 1,3-butanediol
US9562241B2 (en) 2009-08-05 2017-02-07 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene

Also Published As

Publication number Publication date
CN1926240B (en) 2010-06-02
DE602005018898D1 (en) 2010-03-04
EP1706501A2 (en) 2006-10-04
ZA200605764B (en) 2008-08-27
US20090137759A1 (en) 2009-05-28
BRPI0506942A (en) 2007-06-12
AU2005205188A1 (en) 2005-07-28
AU2005205188B2 (en) 2010-11-11
WO2005068643A2 (en) 2005-07-28
TW200526787A (en) 2005-08-16
US7491520B2 (en) 2009-02-17
CN1926240A (en) 2007-03-07
ATE455181T1 (en) 2010-01-15
MY141797A (en) 2010-06-30
EP2194139A1 (en) 2010-06-09
US20070254341A1 (en) 2007-11-01
TWI371490B (en) 2012-09-01
CN102285893A (en) 2011-12-21
EP1706501B1 (en) 2010-01-13
BRPI0506942B1 (en) 2015-07-28

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